Boca Juniors were too good for Athletico Paranaense in the last 16 of the Copa Libertadores.
Boca Juniors earned a dramatic win at Athletico Paranaense in the first leg of their Copa Libertadores last-16 tie.
The draw for the Copa Libertadores round of 16 took place in Paraguay on Monday.
Santiago Arzamendia scored in Tuesday's 1-1 draw away to Uruguayan hosts Nacional as Cerro Porteno topped Group E on goal difference.
Assistant referee Jorge Cruz suffered the embarrassment of having to rush off to the toilet during a Primeira Liga game on Sunday.
Cruzeiro made it five wins from five games in Group B as Atletico Mineiro failed to progress.
Boca Juniors scored four goals against Jorge Wilstermann on Wednesday, after Cruzeiro's Fred celebrated a first-half hat-trick.
Marco Ruben led Athletico Paranaense to an impressive win over Boca Juniors in the Copa Libertadores.
Boca Juniors and Palmeiras both won 3-0 in the Copa Libertadores on Tuesday.
Defending champions River Plate snatched a last-gasp draw at Alianza Lima on Wednesday.