Three big names headed through at Wimbledon on Tuesday, but Dominic Thiem and David Goffin were among those to depart.
Only three sets were required for Novak Djokovic to race past Tennys Sandgren in pursuit of a fourth Wimbledon title.
World number one Simona Halep cruised through her opening Wimbledon match, beating Kurumi Nara 6-2 6-4 on Centre Court.
Having started with a win at Wimbledon, Rafael Nadal was left bemused by questions on his tournament preparations.
There will be no third Wimbledon title for Petra Kvitova in 2018 after she crashed out in the first round on Tuesday.
Dominic Thiem's miserable Wimbledon record continues after the Austrian was forced out of his opening round match with injury.
World number one Rafael Nadal started his quest for a third Wimbledon title with a commanding win over Dudi Sela on Centre Court.
Seven-time Wimbledon champion Serena Williams picked up where she left off in 2016 with victory over Arantxa Rus on Monday.
Serena Williams hopes she can extend her career as long as Roger Federer, after the Swiss hinted at playing for another four years.
Seven-time champion Serena Williams got back to winning ways at Wimbledon on Monday on her first appearance since 2016.