Troubled in the first set, Caroline Wozniacki eventually proved too strong for unseeded American Danielle Collins.
He looked to be struggling with a recurrence of a knee injury during his French Open exit but Stan Wawrinka insists that was not the case.
It was a straight-forward outing for Novak Djokovic at the French Open as he put Rogerio Dutra Silva to the sword in round one.
Guillermo Garcia-Lopez lasted the distance at the French Open against Stan Wawrinka, who endured further problems with his left knee.
After another first-round French Open loss, Johanna Konta said she had lingering doubts in Paris.
Alexander Zverev took just 69 minutes to see off Ricardas Berankis, but David Gofffin had to go the distance to oust Robin Haase.
Jelena Ostapenko ranked her opening-round French Open performance as only 20 per cent of what she is capable of after bowing out on day one.
Alexander Zverev needed little more than an hour to dispatch Ricardas Berankis in the first round of the French Open.
Venus Williams failed to make it out of the first round for a second consecutive grand slam, losing to Qiang Wang in Paris.
An elbow problem has forced Nick Kyrgios to pull out of the French Open at Roland Garros, where he had been due to face Bernard Tomic.