Jack Sock and Sam Querrey put up a valiant effort against two of the game's greats, but were no match for Roger Federer and Rafael Nadal.
The Moselle Open final will see home favourite Benoit Paire take on German Peter Gojowczyk on Sunday.
Roberto Bautista Agut fell short at the semi-final stage once again in St Petersburg as Fabio Fognini and Damir Dzumhur reached the final.
In rallying from behind to defeat Luksika Kumkhum, Jelena Ostapenko made her first final since this year's French Open.
Aleksandra Krunic's first WTA Tour final ended in defeat as Zhang Shuai claimed the Guangzhou Open title for the second time.
Caroline Wozniacki and Anastasia Pavlyuchenkova will meet in the Tokyo Open final after contrasting last-four wins.
Rafael Nadal and Tomas Berdych's defeat in doubles was the only loss of the day for Europe in the Laver Cup.
Puerto Rico's first Olympic gold medallist Monica Puig has surpassed her goal of raising $25,000 for hurricane relief for the island.
The semi-finals of the Moselle Open will have a Frenchman involved after Benoit Paire's hard-fought win over David Goffin.
Jo-Wilfried Tsonga missed out on a place in the last four in St Petersburg as Roberto Bautista Agut reached that stage once again.