Serena Williams and Maria Sharapova face a mouthwatering first-round tie at the US Open, while Novak Djokovic is on the same side of the men's draw as Roger Federer.
Williams will be a heavy favourite given her 19-2 head-to-head record over Sharapova, though it will be the first time the rivals have gone up against each other in New York.
The pair last met on court in the 2016 Australian Open quarter-finals, where Williams was victorious, with a last-16 tie at the 2018 French Open a non-starter due to the American suffering a pectoral injury.
Sharapova has not defeated her illustrious foe in a match since 2004 and faces a monumental challenge against Williams, who was beaten in the final 12 months ago by Naomi Osaka.
Top seed Osaka's bid to defend her title at Flushing Meadows begins against Anna Blinkova, while Kiki Bertens is a potential quarter-final opponent.
Second seed Ashleigh Barty, who made a major breakthrough at Roland Garros, opens up against Zarina Diyas and faces a potential last-eight meeting with Williams.
Karolina Pliskova (3) and Simona Halep (4) each face qualifiers in round one, the latter on a potential last-eight collision course with Petra Kvitova (6).
Defending men's champion Djokovic, aiming to win a third slam of 2019, faces the unheralded Roberto Carballes Baena first but could be set for a daunting run at Flushing Meadows.
Fifth seed Daniil Medvedev, a man in form having reached the finals in Washington and Montreal while also winning the title in Cincinnati, is Djokovic's projected quarter-final opponent, while Federer may stand in the way in the semis.
Five-time champion Federer faces a qualifier first up, while on the other side of the draw Rafael Nadal has a tricky first-round tie with John Millman – who upset Federer in round four a year ago.
Dominic Thiem, Stefanos Tsitsipas and Alexander Zverev could all prove potential road blocks for Nadal in the latter stages.