Experienced England full-back Mike Brown will miss the rest of the Premiership season, Harlequins have confirmed.
England start their Rugby World Cup preparation when they take on Wales on Sunday, and four players have been cut from Eddie Jones' squad.
Eddie Jones' England have made a flying start to the Six Nations and next up is a trip to Cardiff to face Wales.
Manu Tuilagi is back in the England side to face Six Nations champions Ireland almost five years since his last Test start.
With selection for the Six Nations looming, full-back Mike Brown says his burning desire to play for England is as strong as ever.