After opening the scoring with a stunning free-kick away to Catalan rivals Espanyol, Lionel Messi has set yet another LaLiga record.
Espanyol have lost just once at home this season and Ernesto Valverde expects Barcelona to find it hard work in Saturday's derby.
Ahead of the Merseyside derby between Liverpool and Everton, we take a look at some of football's most one-sided rivalries.
Tottenham boss Mauricio Pochettino has the odds against him when he faces Pep Guardiola on Monday - but that has not stopped him previously.
Chelsea and Manchester United take centre stage in our look at some particularly one-sided rivalries.
Tottenham manager Mauricio Pochettino revealed Lionel Messi almost joined him at Espanyol.
More than 250 league appearances for Espanyol left Mauricio Pochettino with too much loyalty to the Parakeets to ever coach Barcelona.
Marco Asensio may be touted as a future Ballon d'Or winner, but the Real Madrid midfielder is unfazed.
Thibaut Courtois did not always look comfortable with the ball at his feet against Espanyol, but Julen Lopetegui dismissed the criticism.
A tight 1-0 defeat of Espanyol came thanks to a first-half Marco Asensio goal, with Raphael Varane hailing Real Madrid's fighting spirit.