Hooker Guilhem Guirado made a nightmare start to his Montpellier career, suffering a long-term injury on his debut against his former club.
Toulouse's contrasting home and away form continued as they defeated visitors and 2018-19 Top 14 final opponents Clermont Auvergne.
An early red card was decisive as Bordeaux-Begles suffered their second defeat of the Top 14 season.
It was another game and another win for Lyon in Top 14, where Castres were defeated by Toulouse on Saturday.
Leaders Lyon are the only unbeaten side in the Top 14 after they won a top-of-the-table encounter against Bordeaux-Begles.
Jake McIntrye amassed 22 points as Clermont Auvergne defeated Top 14 strugglers Stade Francais, as Bordeaux-Begles drew with Montpellier.
Marseille will be without their France international Dimitri Payet for four Ligue 1 games, the Ligue de Football Professionnel confirmed.
Toulon and Agen each won in the Top 14 on Sunday, with Racing 92 unable to complete a turnaround while Montpellier were outplayed.
The top two in the Top 14 both triumphed on Saturday, with Bordeaux-Begles and Lyon improving to three wins from three this season.
The second round of Top 14 fixtures saw hard-fought wins for Clermont Auvergne, La Rochelle and Montpellier, among others, on Saturday.