Two-time Wimbledon champion Petra Kvitova's participation in this year's event is in doubt after she withdrew from the Birmingham Classic.
With Karolina Pliskova, Kiki Bertens, Petra Kvitova and Angelique Kerber out of the French Open, Naomi Osaka will remain world number one.
Diane Parry put Amelie Mauresmo's lesson into practice, while Kiki Bertens and Serena Williams were round one winners at the French Open.
Having played through the pain in recent weeks, an arm injury will keep Petra Kvitova out of the French Open.
While Simona Halep insisted fitness was not an issue ahead of the French Open, Naomi Osaka eased through at the Internazionale d'Italia.
The Madrid Open final will see Kiki Bertens look to go one better than last year when she faces Simona Halep, eyeing a return to number one.
The top two seeds crashed out of the Madrid Open on Thursday, leaving Simona Halep primed for success and a return to number one.
The last four WTA Madrid Open titles have been shared by Simona Halep and Petra Kvitova and both remain in contention this year.
Defending champion Petra Kvitova made it through to the third round in Madrid along with the likes of Sloane Stephens and Ashleigh Barty.
Three-time champion Petra Kvitova made 38 unforced errors, but was still able to get past Kristina Mladenovic.