Jamie Vardy scored twice as Leicester City racked up yet another win, while there were victories for Sheffield United and Newcastle United.
The battle to bring Jadon Sancho back to England is heating up, with three Premier League clubs going head-to-head.
The Manchester derby takes centre stage in the Premier League this weekend – have a go at our weekly quiz, powered by Opta.
Jose Mourinho's perfect record as Tottenham boss is over after a defeat at Manchester United while Liverpool won the Merseyside derby.
Manchester City have a favourable draw in the FA Cup third round, but there are difficult trips for Everton and Manchester United.
Manchester United host obliging opposition in Aston Villa as Burnley try to equal a record - have a go at our weekly quiz, powered by Opta.
Sofiane Boufal is a doubt for Southampton's crunch Watford clash, having injured his toe running into his kitchen table.
Arsenal head coach Unai Emery is under growing pressure after a six-match winless run but is confident he has the backing of his bosses.
Arsenal have failed to win their past five Premier League matches and Pierre-Emerick Aubameyang called for efforts to be redoubled.
There were five away wins in the 3pm Premier League kick-offs on a day when Jose Mourinho took charge of Tottenham for the first time.