Stuart Broad and Sam Curran were in devastating form as England dismantled South Africa and enforced the follow-on.
Owen Farrell, Maro Itoje and the Vunipola brothers will all likely become available after Saracens were relegated from the Premiership.
England are in a strong position following Dom Bess' first Test five-for, but Quinton de Kock and rain held the tourists up.
England took control of the third Test against South Africa on Friday, with Ollie Pope revelling in his maiden century.
Head coach Mark Boucher said Kagiso Rabada will have to learn to keep his emotions in check, but suggested his ban was harsh.
Harry Kane faces a race to be fit for Euro 2020, and Liverpool's Jurgen Klopp pointed to the demands on players as he called for FA action.
When is a declaration not a declaration? England answered the question on Friday after the decision to give Mark Wood out was overturned.
England's Ben Stokes made history in Port Elizabeth as the all-rounder joined an exclusive club of Test players.
Ashley Young's impending departure to Inter has persuaded Ole Gunnar Solskjaer to name Harry Maguire as Manchester United captain.
South Africa seamer Kagiso Rabada has collected his fourth demerit point in 24 months and will miss the fourth Test with England.