Antonio Valencia, who is set to leave Manchester United at the end of 2018-19, has returned to training ahead of the trip to Huddersfield.
Manchester United defender Eric Bailly suffered a knee injury in the Red Devils' draw with Chelsea on Sunday.
Goals from Bernardo Silva and Leroy Sane condemned Manchester United to defeat in the derby, with Marcus Rashford critical of his side.
Ole Gunnar Solskjaer's Manchester United go into Wednesday's derby in dire form and five players in particular need to prove a point.
Ole Gunnar Solskjaer has brought in Anthony Martial to partner Marcus Rashford as Manchester United take on Barcelona.
Manchester United face Barcelona on Wednesday with back-up midfield options, but Marcus Rashford is able to start.
Marcus Rashford and Nemanja Matic could feature against Barcelona but the game will come too soon for Alexis Sanchez and Ander Herrera.
Games against Manchester City, PSG, Juventus and Roma offer Manchester United a blueprint in how to face Barcelona.
Paul Pogba struggled to influence Manchester United's win over Watford, leading Ole Gunnar Solskjaer to suggest tweaking his position.
Manchester United were far from convincing as they beat Watford 2-1, and Luke Shaw conceded it was a performance to forget.