Santiago Arzamendia scored in Tuesday's 1-1 draw away to Uruguayan hosts Nacional as Cerro Porteno topped Group E on goal difference.
Palmeiras reached the knockout phase thanks to a 4-0 rout of Melgar, while San Lorenzo also progressed despite their 1-0 loss to Junior.
Boca Juniors scored four goals against Jorge Wilstermann on Wednesday, after Cruzeiro's Fred celebrated a first-half hat-trick.
Nicolas De La Cruz's spectacular free-kick helped River Plate earn a draw at Internacional in the Copa Libertadores.
Playing behind closed doors at the Monumental, River Plate were held by Palestino in the Copa Libertadores.
Defending champions River Plate snatched a last-gasp draw at Alianza Lima on Wednesday.
We assess the leading candidates for glory and the potential stars ahead of the start of the 2019 Copa Libertadores.
With a last-16 spot on the line, Gremio made no mistake in the Copa Libertadores.
Despite being held to a draw at home, Godoy Cruz advanced to the Copa Libertadores knockout stages.
Trailing 3-2 in the 90th minute, Rafael Caroca and Diego Bielkiewicz scored as hosts Deportes Iquique prevailed in a seven-goal thriller.