Gremio only have one point from three Group H fixtures following Thursday's 1-0 loss away to Universidad Catolica.
Nicolas De La Cruz's spectacular free-kick helped River Plate earn a draw at Internacional in the Copa Libertadores.
Marco Ruben led Athletico Paranaense to an impressive win over Boca Juniors in the Copa Libertadores.
Rodriguinho's seventh-minute opener and Jadson's last-gasp strike saw Cruzeiro account for Deportivo Lara in Group B on Wednesday.
Lucas Viatri led Penarol to a comprehensive win over San Jose in the Copa Libertadores.
Playing behind closed doors at the Monumental, River Plate were held by Palestino in the Copa Libertadores.
Boca Juniors and Palmeiras both won 3-0 in the Copa Libertadores on Tuesday.
Emelec failed to open their Copa Libertadores campaign with a win as Brayan Angulo's missed penalty proved crucial against Deportivo Lara.
Cruzeiro edged Huracan in wet conditions, while Deportivo Lara's clash against Emelec had to be rescheduled due to a floodlight issue.
Defending champions River Plate snatched a last-gasp draw at Alianza Lima on Wednesday.