Lucas Viatri led Penarol to a comprehensive win over San Jose in the Copa Libertadores.
Playing behind closed doors at the Monumental, River Plate were held by Palestino in the Copa Libertadores.
Boca Juniors and Palmeiras both won 3-0 in the Copa Libertadores on Tuesday.
Emelec failed to open their Copa Libertadores campaign with a win as Brayan Angulo's missed penalty proved crucial against Deportivo Lara.
Cruzeiro edged Huracan in wet conditions, while Deportivo Lara's clash against Emelec had to be rescheduled due to a floodlight issue.
Defending champions River Plate snatched a last-gasp draw at Alianza Lima on Wednesday.
Last season's runners-up Boca Juniors were held by Bolivian hosts Jorge Wilstermann in Group G on Tuesday.
We assess the leading candidates for glory and the potential stars ahead of the start of the 2019 Copa Libertadores.
The Club World Cup might have brought defeat to Al Ain but River Plate boss Marcelo Gallardo knows his team have gone down in history.
After upstaging bitter rivals Boca Juniors for a fourth Copa Libertadores crown, River Plate were drawn in Group A for the 2019 edition.