Baghdad Bounedjah scored an 83rd-minute penalty as Al Sadd beat Al-Nassr 3-1 in Monday's second leg to advance 4-3 on aggregate.
Ryohei Shirasaki struck the crossbar late on as Kashima Antlers claimed a 0-0 draw at Guangzhou Evergrande in their quarter-final first leg.
Al-Ittihad and Al-Hilal's AFC Champions League quarter-final is perfectly poised after a goalless first-leg draw.
Shanghai SIPG were indebted to their Brazilian striker Hulk for his spot-kick double against Urawa Red Diamonds at the Shanghai Stadium.
Xavi's Al Sadd took the lead in Monday's AFC Champions League quarter-final first leg, but Al-Nassr came from behind to win 2-1.
Al Sadd saw off Al Duhail in the AFC Champions League last 16, while Al-Hilal survived against Al-Ahli.
Al-Nassr and Al-Ittihad reached the quarter-finals of the AFC Champions League after respective high-scoring wins in the last 16.
Xavi was always a composed player on the pitch, but he did not manage to retain his cool demeanour during his coaching debut for Al-Sadd.
Al-Hilal twice came from behind to claim a 4-2 win at Al-Ahli in the AFC Champions League thanks to Bafetimbi Gomis' hat-trick.
Zobahan went down to a 2-1 loss after leading at Al-Ittihad in their AFC Champions League last-16 encounter on Monday.