Giovani dos Santos scored twice as LA Galaxy extended their unbeaten run in MLS.
The San Jose Earthquakes ended Dallas' unbeaten start to the MLS season.
Gerso Fernandes scored a 13-minute treble to inspire Sporting KC's 3-0 victory at home to Seattle Sounders on Wednesday.
Sebastian Giovinco was on target as Toronto FC extended their winning streak to a club record six games after edging Minnesota United 3-2.
Brek Shea came off the bench to score a winner for Vancouver Whitecaps against Colorado Rapids in MLS.