New York Red Bulls used a blistering start to claim bragging rights, two goals inside the opening four minutes inspiring a crushing victory.
David Villa celebrated a memorable milestone, while LAFC's first match at their new stadium ended in dramatic fashion.
LAFC rallied to a 5-3 victory over 10-man Montreal Impact, having trailed 3-1 at half-time, while Houston Dynamo crushed Toronto.
LA Galaxy star Zlatan Ibrahimovic scored the winning goal against Chicago Fire Saturday.
A week on from their dramatic derby defeat, LAFC's defensive woes continued against Atlanta United.
A 40-yard stunner and a 91st-minute winner were on the script as Zlatan Ibrahimovic came off the bench to lift LA Galaxy past LAFC 4-3.
The New York Red Bulls were too good for Minnesota United thanks to a Bradley Wright-Phillips brace.
LAFC continued where they left off Saturday, crushing hosts RSL thanks to Diego Rossi's brace and a goal from Carlos Vela.
Tigres UANL reached the CONCACAF Champions League quarter-finals as Enner Valencia starred.
Sebastian Giovinco scored and provided an assist as Toronto beat Colorado Rapids in the CONCACAF Champions League.