A free-kick from Alan Pulido saw Guadalajara to a 2-1 win over Toronto in the CONCACAF Champions League final first leg.
Toronto and Guadalajara will go head-to-head in the two-legged CONCACAF Champions League final following Tuesday's results.
Isaac Brizuela's first-half goal was all that separated Guadalajara and New York Red Bulls in a feisty clash in Mexico on Wednesday.
Club America staff were assaulted by police in Toronto on Tuesday, claimed Miguel Herrera, but local authorities received no complaints.
Sebastian Giovinco inspired Toronto, the Italian opening the scoring before Jozy Altidore and Ashtone Morgan settled Tuesday's fixture.
Mexican giants America were comfortable 3-1 victors over Tauro in Panama as they sealed a final-four berth.
MLS Cup champions Toronto were beaten at Tigres UANL but still moved into the CONCACAF Champions League semi-finals.
Jonathan Osorio produced a moment of brilliance thanks to a sensational backheel with a minute of regulation time remaining to lift Toronto.
Seven-time champions America humbled Panamanian visitors Tauro 4-0 in Tuesday's quarter-final first leg.
Clint Dempsey and Nicolas Lodeiro helped the Seattle Sounders book their spot in the CONCACAF Champions League quarter-finals.