Enner Valencia helped Tigres UANL beat Houston Dynamo in the first leg of their CONCACAF Champions League quarter-final.
Atlanta United cruised to a 4-0 rout of Herediano, which completed a come-from-behind 5-3 aggregate triumph for Frank de Boer's side.
Sean Davis, Daniel Royer and Andreas Ivan were on target for New York Red Bulls, who won 5-0 on aggregate in the round of 16.
Tigres UANL reached the CONCACAF Champions League quarter-finals thanks to hat-trick hero Enner Valencia.
Frank de Boer made a losing start to life as coach of Atlanta United, who were beaten by Herediano.
Javier Correa netted three goals within 19 minutes before half-time as Santos Laguna cruised to victory against Marathon on Wednesday.
Toronto FC will have to overturn a four-goal deficit if they are to progress to the quarter-finals of the CONCACAF Champions League.
Guadalajara won their first CONCACAF Champions League title since 1962 after outlasting Toronto in the two-legged final.
A free-kick from Alan Pulido saw Guadalajara to a 2-1 win over Toronto in the CONCACAF Champions League final first leg.