Monterrey continued Frank de Boer's difficult start to life as Atlanta United head coach.
Enner Valencia helped Tigres UANL beat Houston Dynamo in the first leg of their CONCACAF Champions League quarter-final.
Atlanta United cruised to a 4-0 rout of Herediano, which completed a come-from-behind 5-3 aggregate triumph for Frank de Boer's side.
Sean Davis, Daniel Royer and Andreas Ivan were on target for New York Red Bulls, who won 5-0 on aggregate in the round of 16.
Tigres UANL reached the CONCACAF Champions League quarter-finals thanks to hat-trick hero Enner Valencia.
Frank de Boer made a losing start to life as coach of Atlanta United, who were beaten by Herediano.
Javier Correa netted three goals within 19 minutes before half-time as Santos Laguna cruised to victory against Marathon on Wednesday.
Toronto FC will have to overturn a four-goal deficit if they are to progress to the quarter-finals of the CONCACAF Champions League.
Guadalajara won their first CONCACAF Champions League title since 1962 after outlasting Toronto in the two-legged final.
A free-kick from Alan Pulido saw Guadalajara to a 2-1 win over Toronto in the CONCACAF Champions League final first leg.