Ireland were dismissed for only 70 in reply to India's imposing total of 213-4, KL Rahul and Suresh Raina leading the way for the tourists.
Israel Folau is set to miss the Waratahs' Super Rugby clash with the Rebels after he was suspended on Wednesday.
India were comfortable from start to finish against Ireland, beginning their tour with a Twenty20 triumph.
Peter Stringer played 98 times for Ireland and won the Grand Slam during his distinguished 11-year international career.
Simon Cron would be "stunned" if Israel Folau is banned as the Waratahs prepare to face the Rebels without the injured Michael Hooper.
Michael Cheika was bemused by a number of decisions in Australia's loss to Ireland, but the referee was in no mood to explain himself.
Ireland made history by beating Australia in Sydney and Joe Schmidt hopes their victory will bode well for the future.
A scrappy encounter between Australia and Ireland in Sydney saw the visitors edge to victory and clinch the series.
Peter O'Mahony knows it would be a major achievement to mark his 50th cap by inspiring Ireland to a series win over Australia.