The top two in the Top 14 claimed huge victories to stay unbeaten as both the defending champions and last year's runners-up were beaten.
Clermont Auvergne suffered a derby defeat to Top 14 new boys Brive as defending champions Toulouse earned their first win of the season.
Toulouse won the Top 14 last season but they have been beaten in each of their first two matches at the start of the 2019-20 campaign.
After Toulouse beat Clermont Auvergne to win the Top 14 title for the 20th time, Ugo Mola paid tribute to his players.
Toulouse won the Top 14 final for the first time in seven years thanks to Yoann Huget's double against Clermont Auvergne.
Toulouse booked their place in a Top 14 final for the first time since 2012 after they overcame La Rochelle in Bordeaux.
Neither Bordeaux Begles nor Stade Francais can make the play-offs in the Top 14 after suffering painful defeats in the penultimate round.
Leinster remain on course to retain their European Champions Cup crown, but Garry Ringrose believes Saracens will be tough final opponents.
Holders Leinster will have the chance to retain their European Champions Cup crown after defeating Toulouse in Dublin on Sunday.
Sunday's semi-final against Leinster will see Toulouse players wearing a special kit that includes an image of Notre Dame.