Tottenham are the latest club to try their luck versus Real Madrid at Santiago Bernabeu, while Man City and Napoli look set for a goal-fest.
With an injury-hit Feyenoord side soundly beaten by Napoli, coach Giovanni van Bronckhorst acknowledged that they made too many errors.
While Napoli were good value for their 3-1 win over Feyenoord, coach Maurizio Sarri was angry to see their goal difference take a late hit.
Napoli made light work of Feyenoord in the Champions League on Tuesday, taking time out to pay tribute to injured star Arkadiusz Milik.
Borussia Dortmund and Real Madrid are familiar foes - and they meet yet again in the Champions League on Tuesday.
Napoli's San Paolo stadium will only have home fans for their Champions League clash with Feyenoord, after a local government ruling.
Having impressed in his first 90 minutes for Manchester City at Feyenoord, Portugal star Bernardo Silva is primed for more action.
Manchester City flew out of the blocks to sour Feyenoord's Champions League return on a frustrating night for the Dutch title holders.
Manchester City manager Pep Guardiola nurtured Lionel Messi and Andres Iniesta but feels Kevin De Bruyne is one of the best he's work with.
John Stones was the unlikely two-goal hero for Manchester City as Feyernoord were put to the sword and Pep Guardiola hailed the England man.