Ukraine international Marlos bagged a brace against Feyenoord as Shakhtar Donetsk strengthened their grip on second spot in Group F.
Harry Kane and Cristiano Ronaldo come head-to-head on Wednesday, having scored more goals than anyone else in this year's Champions League.
Kasper Dolberg scored twice and David Neres was the architect as Ajax proved too strong for Feyenoord on Sunday.
Feyenoord are without a point after three Champions League games but Giovanni van Bronckhorst has not given up hope of the knockout stage.
Feyenoord have lost their last 10 Champions League matches after slipping to a 2-1 home defeat to Shakhtar Donestk
Tottenham are the latest club to try their luck versus Real Madrid at Santiago Bernabeu, while Man City and Napoli look set for a goal-fest.
With an injury-hit Feyenoord side soundly beaten by Napoli, coach Giovanni van Bronckhorst acknowledged that they made too many errors.
While Napoli were good value for their 3-1 win over Feyenoord, coach Maurizio Sarri was angry to see their goal difference take a late hit.
Napoli made light work of Feyenoord in the Champions League on Tuesday, taking time out to pay tribute to injured star Arkadiusz Milik.
Borussia Dortmund and Real Madrid are familiar foes - and they meet yet again in the Champions League on Tuesday.