An entirely one-sided second half saw St Helens make it six wins from six in Super League this season.
Huddersfield Giants claimed their first win of the season to add to Wigan's woes, while St Helens and Hull FC claimed emphatic victories.
James Roby scored two tries as St Helens recorded a 26-4 win over Salford Red Devils to move two points clear at the summit.
Alex Walmsley ran in two tries as St Helens scored 17 unanswered points in the second half to defeat Leeds Rhinos on Friday.
There were wins for St Helens and Salford Red Devils in Super League on Sunday.
Jonny Lomax has followed James Roby and Tommy Makinson in signing new deals with St Helens.
A month before his NRL return, Ben Barba has been sacked by the North Queensland Cowboys after a "significant" contract breach.
Super League returned with a bang on Thursday as St Helens defeated the 2018 champions, Wigan Warriors, in an intense contest.
Justin Holbrook is confident his St Helens side are "ready to go" as they aim to improve on a painful semi-final exit last season.
Despite receiving offers to move to the NRL, winger Tommy Makinson will be staying at St Helens until the end of the 2022 season.