Shaun Stevenson scored a hat-trick of tries as the Chiefs tore apart the Rebels to qualify for the Super Rugby play-offs in style.
The Crusaders ensured they will finish top of the table in Super Rugby after battering the Rebels on Saturday.
The Blues looked set to claim a dramatic Super Rugby win over the Bulls, but Harry Plummer failed to convert a late penalty.
The Blues have now suffered 10 consecutive losses to the Crusaders after Super Rugby's leaders edged a tense Christchurch encounter.
Will Genia's head injury was the only disappointment for the Rebels as they thrashed the rock-bottom Sunwolves in Tokyo on Saturday.
The Hurricanes, who were without Beauden Barrett, succumbed to their first ever loss to the Jaguares on Friday.
Two yellow cards proved costly as the Reds were beaten by the Rebels, while the Hurricanes picked off the Blues at Eden Park.
Adam Coleman will join Waisake Naholo, Sekope Kepu, Paddy Jackson and other new signing at London Irish in the Premiership next season.
The Hurricanes scored 26 points in the opening 22 minutes to beat the Rebels, while the Chiefs came back to draw 31-31 with the Highlanders.
Kurtley Beale started at full-back in place of Israel Folau and the Waratahs showed great spirit to overcome the Rebels at the SCG.