Robert Du Preez scored 38 points in a big win for the Blues in Auckland, while Bernard Foley made history in a Waratahs win.
The Brumbies hope to have Australia international David Pocock back for this weekend's Super Rugby clash with the Waratahs.
Henry Speight signed an extension with Rugby Australia to remain with the Wallabies and Brumbies.
The Crusaders only lost one match last season, but have already been beaten twice in 2018 after a derby loss to the Highlanders.
Reece Hodge starred as the Rebels raced to yet another big Super Rugby win, seeing off conference rivals Brumbies on Friday.
The Chiefs beat the Blues even without a host of players due to injury, while the Reds triumphed despite two key suspensions.
Defending champions the Crusaders scored seven tries to get start their Super Rugby season with a hard-fought win over the Chiefs.
Brumbies back-rower David Pocock has been ruled out for three months due to a knee operation.
He is only contracted to Ulster until January, but Brumbies fly-half Christian Lealiifano would be open to remaining for longer.
Stormers will host Jaguares in the first game of a revised Super Rugby competition on February 2017.