London Broncos' brave bid to retain their Super League status came up short, while Salford Red Devils claimed third place in the table.
Jay Pitts' late try means London Broncos remain in with a chance of beating the drop, while also leaving Hull KR in deep trouble.
A 36-10 win over London Broncos means Leeds Rhinos can put a forgettable Super League campaign behind them and not worry about relegation.
Wakefield Trinity stylishly claimed just a second victory in 13 Super League matches, beating fellow strugglers Hull KR 38-10.
Ratu Naulago scored twice as Hull FC eased past Super League strugglers Wakefield Trinity on Sunday.
Huddersfield Giants were torn apart by struggling Leeds Rhinos at their own ground in Super League on Friday.
Wigan Warriors crushed Wakefield Trinity in a one-sided encounter at the DW Stadium, Liam Farrell leading the way with three tries.
Super League table-toppers St Helens moved 10 points clear after a 32-10 win over Wigan Warriors, while Salford surprised Warrington.
A dominant first-half display from Warrington Wolves saw them blow struggling London Broncos away on the road on Saturday.
Warrington Wolves looked set to close the gap on Super League leaders St Helens, but Jonny Lomax inspired his side to yet another victory.