Saracens knew they would be relegated at the end of the season, and a 70-point penalty ensures they will finish bottom of the Premiership.
In their first Premiership outing since their automatic relegation was confirmed, Saracens were soundly beaten by London rivals Harlequins.
Exeter Chiefs rallied in the second half against Sale Sharks, but the Premiership leaders still slipped to a first defeat since November.
Northampton Saints looked to be heading top of the Premiership until London Irish sprung a shock following Api Ratuniyarawa's dismissal.
Michael Fatialofa is showing "encouraging signs of improvement" and has been moved to the Major Trauma Unit at St Mary's Hospital.
Saracens owner Nigel Wray apologised for his "ill-considered approach" after a report detailed how Saracens fell foul of salary-cap rules.
Saracens have given Premiership Rugby permission to release the full report into their salary cap breaches, which have led to relegation.
England captain Owen Farrell had the chance to confirm he would stay with crisis-hit Saracens, but instead he said talks were "ongoing".
France captain Charles Ollivon does not believe Saracens' impending relegation from the Premiership will have any impact on England.
Wayne Pivac is hoping Liam Williams will make his comeback from an ankle injury in the second round of the Six Nations against Ireland.