Luis Rodriguez's 77th-minute volley saw Mexico overcome Ecuador in an international friendly.
Arthur was substituted after he was injured in a heavy challenge as Honduras were routed 7-0 by Brazil in a pre-Copa America friendly.
Venezuela was comfortable winners over the United States in Cincinnati, where Salomon Rondon scored a first-half brace and assisted another.
Venezuela were comfortable winners over the United States in Cincinnati, where Salomon Rondon scored a first-half brace and assisted another
Tite is already without star forward Neymar due to injury and Arthur could also be a doubt after a bad tackle against Honduras.
Paris Saint-Germain star Neymar missing the Copa America in Brazil is a blow for head coach Tite.
PSG reassessed Neymar and the Ligue 1 champions said he will not require ankle surgery after being diagnosed by the club's doctors.
In his first game for over a month, Luis Suarez netted a free-kick for Uruguay and impressed Oscar Tabarez ahead of the Copa America.
Two goals from Lionel Messi and Lautaro Martinez saw Argentina past Nicaragua before their Copa America opener on June 15.
Luis Suarez scored a wonderful free-kick in Uruguay's friendly victory over Panama in Montevideo.