Dominic Thiem was a surprise casualty at the Monte Carlo Masters, while there were serene wins for Rafael Nadal and Novak Djokovic.
Grigor Dimitrov was no match for Rafael Nadal, who breezed into the Monte Carlo Masters quarter-finals.
Daniil Medvedev awaits Novak Djokovic in the Monte Carlo Masters quarter-finals after the world number one defeated Taylor Fritz.
Kei Nishikori was the biggest scalp of Wednesday's play at the Monte Carlo Masters, as Rafael Nadal and Dominic Thiem raced through.
World number two Rafael Nadal may take some stopping as he chases a 12th Monte Carlo Masters title, having thrashed Roberto Bautista Agut.
Marin Cilic and Karen Khachanov crashed out of the Monte Carlo Masters, while Jo-Wilfried Tsonga was forced to retire due to injury.
Philipp Kohlschreiber again caused Novak Djokovic problems on Tuesday, but the world number one was able to advance in Monte Carlo.
Roger Federer's mark of 18 wins on the ATP Tour this season was equalled by Daniil Medvedev at the Monte Carlo Masters on Monday.
Christian Garin earned his maiden ATP crown thanks to Sunday's hard-fought 7-6 (7-4) 4-6 6-3 victory over Casper Ruud in Houston.