Connacht had no answer to Chris Ashton, who enjoyed a hat-trick on his competitive debut for Sale Sharks.
Wasps, without Christian Wade, battled back to draw with Bath, and Edinburgh battered Toulon in Saturday's European Champions Cup action.
Christian Wade has been heavily linked with a career switch to the NFL, but Wasps boss Dai Young insists for now it is mere speculation.
Gloucester could be set for a prolonged spell without Danny Cipriani, who was shown a red card for a high shot on Munster's Rory Scannell.
Australia dominated the first half in Auckland to set up a comfortable victory over Tonga, Valentine Holmes scoring 18 points.
Having been beaten 82-21 by La Rochelle six days earlier, Enisei were once again outplayed by the French club.
The 71st European tie hosted at Welford Road ended in a 45-27 win for Leicester Tigers over the Scarlets in the European Champions Cup.
Zak Hardaker has vowed to do all he can to repay the faith Super League champions Wigan Warriors have put in him.
Wasps have not made any comment on reports that Christian Wade, who will not play against Bath, is set for a sensational move to the NFL.
Courtney Lawes had been linked with a move to the Top 14, but the long-serving lock will be staying at Franklin's Gardens.