For the first time in Wimbledon history not one of the top-10 seeds in the women's draw made it into the last eight.
Simona Halep and Karolina Pliskova are the only remaining seeds from the top 10 at Wimbledon after a first week of shocks.
The exodus of seeds from the women's draw continued at Wimbledon, where American duo Venus Williams and Madison Keys bowed out on Friday.
A day on from Petra Kvitova's surprise Wimbledon departure, Caroline Wozniacki joined the pre-tournament favourite in making an early exit.
A ball boy was helped off after being flattened by Damir Dzumhur and Novak Djokovic showed plenty of aggression on a grey day in Paris.
There were wins for Simona Halep and Caroline Wozniacki at the French Open on Wednesday.
Jelena Ostapenko ranked her opening-round French Open performance as only 20 per cent of what she is capable of after bowing out on day one.
Venus Williams failed to make it out of the first round for a second consecutive grand slam, losing to Qiang Wang in Paris.
The Williams sisters will look to add to their two French Open doubles titles after being handed a wildcard for Roland Garros.
While Simona Halep enjoyed a walkover, Caroline Wozniacki needed three sets to defeat Anastasija Sevastova and reach the last eight.