Ruben Neves, Matt Doherty and Diogo Jota were on target as Wolves inflicted a second consecutive Premier League defeat on Arsenal.
Sokratis Papastathopoulos has enjoyed a strong debut season at Arsenal and Unai Emery is depending on him against Napoli.
Sokratis Papastathopoulos, Lucas Torreira and Alexandre Lacazette have been sent off inside a month but Unai Emery does not see a problem.
Arsenal could only draw with Tottenham on Saturday, but Sokratis Papastathopoulos applauded the Gunners' mentality.
Bouncing back from a tough first leg, Arsenal cruised through in the Europa League with a dominant display against BATE on Thursday.
Arsenal will face BATE on Thursday without Mesut Ozil, Aaron Ramsey or Sokratis Papastathopoulos, but Denis Suarez could be involved.
Arsenal's injuries continue to mount, with no timescale put on Laurent Koscielny's return while Sokratis Papastathopoulos will miss a month.
Arsenal have plenty of room to improve even after stretching their undefeated run to 17 games, according to Sokratis Papastathopoulos.
Unai Emery hopes for some good news on the injury front ahead of Arsenal's meeting with Liverpool on Sunday.
Having won the Europa League three years in a row with Sevilla, Arsenal head coach Unai Emery has hailed the tournament's importance.