After a brace against Eibar, Lionel Messi finished the league season with 36 goals, earning him a record-equalling sixth Pichichi award.
Jan Oblak has been in inspired form for Atletico Madrid but he has played his final game of the season because of a thigh injury.
Atletico Madrid were given a reprieve by VAR in their win over Real Valladolid, and Diego Simeone sympathised with the strugglers.
Barcelona will have to beat Levante to be champions this weekend, with Atletico Madrid having scraped a 1-0 win over Real Valladolid.
Jan Oblak, who has extended his Atletico Madrid contract through to 2023, is "probably the best keeper in the world", says Diego Simeone.
Atletico Madrid have tied Slovenia international Jan Oblak, widely considered one of the world's best goalkeepers, to a new four-year deal.
Jan Oblak was in fine form to deny Celta Vigo on Saturday and Diego Simeone is in no doubt that he is the world's best in his position.
Jan Oblak made a sensational early save, but Atletico Madrid's 18-match unbeaten run in LaLiga came to an end with a defeat at Real Betis.
Luka Modric is expected to win the Ballon d'Or, with Barcelona superstar Lionel Messi not even in the top three for the 2018 prize.
The top 10 of the Ballon d'Or is yet to be confirmed, but it will not include Luis Suarez, Paul Pogba or Neymar.