Josef Martinez and Miguel Almiron helped Atlanta United come from behind to beat the San Jose Earthquakes.
Zlatan Ibrahimovic reached the milestone in LA Galaxy's 5-3 defeat at defending champions Toronto on Saturday.
Felipe Gutierrez's goal saw Sporting Kansas City to a narrow win over Orlando City in MLS.
Zlatan Ibrahimovic's LA Galaxy were put to the sword by Real Salt Lake, despite a dream start in MLS action on Saturday.
Brian White's first MLS goal lifted the New York Red Bulls to the top of the Eastern Conference.
Alejandro Romero Gamarra – better known as Kaku – was the hero as his thunderous effort lifted the New York Red Bulls past DC United.
New York Red Bulls earned top spot in the Eastern Conference courtesy of a late equaliser, as FC Dallas ended a short losing streak.
Wayne Rooney continued his red-hot form by scoring twice against Portland Timbers at Audi Field in Washington on Wednesday.
Eastern Conference leaders Atlanta United may be looking over their shoulder at New York Red Bulls, while Portland Timbers finally lost.
Western Conference leaders FC Dallas were surprisingly beaten at home in MLS on Sunday, as Orlando City earned a thrilling draw.