Manchester United's problems on the road continued with a 2-0 defeat at West Ham, while leaders Liverpool made it six wins out of six.
Ainsley Maitland-Niles was sent off for Arsenal but late goals from Calum Chambers and Pierre-Emerick Aubameyang gave them all three points.
Unai Emery has made just one change to his starting XI from the side that drew with Watford last weekend for the visit of Aston Villa.
The Football Association has fined Birmingham City after a controversial derby clash with Aston Villa in March.
Aston Villa and West Ham have won three league games between them this season, with Monday's draw perhaps unsurprisingly short on quality.
John Terry's presence at Aston Villa has been a boost to Tyrone Mings' development, the defender said ahead of a potential England debut.
Liverpool were quiet but Real Madrid and Barcelona spent heavily in the transfer window in a bid for LaLiga and Champions League glory.
Manchester City recorded an emphatic win over Brighton in the Premier League, but Manchester United and Chelsea could only draw.
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League Two sides Crawley Town and Colchester United shocked their Premier League opponents in the EFL Cup.