Hans Hateboer scored in either half as Gian Piero Gasperini's Atalanta blew away Valencia in their last-16 first-leg clash.
Jonathan Ikone scored in second-half stoppage-time to rescue a 1-1 draw for Lille against 10-man Valencia.
Kostas Laifis' first-half red card for Cyprus helped Russia earn a 5-0 win to secure their spot at Euro 2020.
The Spanish FA were unimpressed with VAR images relating to Denis Cheryshev's controversial goal for Valencia against Athletic Bilbao.
Russia winger Denis Cheryshev has sealed his permanent move to Valencia, where his contract includes an €80million buyout clause.
Russia winger Denis Cheryshev is set to return to Valencia as he brings an end to his time at Villarreal.
Copa del Rey finalists Valencia will be without Russia international Denis Cheryshev for the rest of the season due to a knee injury.
Goals from Denis Cheryshev and Ruben Sobrino secured Valencia a handy lead to take back to Mestalla after the first leg against Celtic.
Valencia scored twice in the last 20 minutes to draw 2-2 at Real Betis in the Copa del Rey semi-final first leg, frustrating Quique Setien.
Goals from Loren Moron and Joaquin gave Real Betis a first-leg advantage over Valencia but Denis Cheryshev and Kevin Gameiro struck back.