Cruzeiro moved into the Copa Libertadores knockout stage after a win against Racing Club.
Goals from Jaime Valdes and Esteban Paredes saw Colo-Colo edge Delfin in the Copa Libertadores.
Cruzeiro claimed their first win of the Copa Libertadores group stage in impressive fashion.
Lisandro Lopez was twice denied by Vasco goalkeeper Martin Silva from the penalty spot before finally scoring in the second half.
Boca Juniors opened their 2018 account with a 1-0 win at home to Junior in Buenos Aires on Wednesday, while Gremio and Penarol also won.
Racing Club and Atletico Nacional claimed wins as the Copa Libertadores group stage got underway.