Martin Caceres was sent off in the first half but Darwin Nunez struck late as Uruguay drew with Peru in Lima.
Brian Rodriguez's winner helped Uruguay exact some revenge on Peru, who had knocked them out of the Copa America earlier this year.
Brazil's 17-game unbeaten run came to an end in September when they lost to Peru, but they will hope to get back on track against Senegal.
Neymar started on the bench as Brazil lost to Peru, but Tite defended his team selection in Los Angeles.
Vinicius Junior's Brazil debut was an underwhelming affair but Casemiro, his Real Madrid team-mate, wants him to "think big".
Brazil lost to Peru on Tuesday, dealt their first defeat in over a year, but Fagner hoped to use the experience as a positive.
Luis Abram's 85th-minute header saw Peru past Brazil, while condemning the Selecao to their first defeat since the 2018 World Cup.
Neymar was a topic of conversation once again as Brazil prepare to face Peru in a rematch of the Copa America final.
The rivalry between Pep Guardiola and Jurgen Klopp has been renewed in the nominations for the The Best FIFA Men's Coach award.
Brazil forward Gabriel Jesus does not believe he should have been sent off in the Copa America final but is sorry for his response.