Goals from Dudu and Miguel Borja guided Palmeiras to another win over Colo-Colo.
Luiz Felipe Scolari's Palmeiras left with two priceless away goals in the quarter-final first leg thanks to Bruno Henrique and Dudu.
River Plate were too good for Racing Club to move into the quarter-finals of the Copa Libertadores.
Ramon Abila and Mauro Zarate were on target in the first half as Boca Juniors defeated Libertad 2-0 in Buenos Aires.
Juan Ferney Otero scored two second-half penalties to lead Estudiantes past Nacional in the Copa Libertadores.
Gremio and Cerro Porteno advanced from Group One with respective wins over Monagas and Defensor Sporting on Tuesday.
Goals from Jaime Valdes and Esteban Paredes saw Colo-Colo edge Delfin in the Copa Libertadores.
Arthur Gomes was the hero for Brazilian visitors Santos, who moved top of Group Six with a 1-0 victory at Estudiantes on Thursday.
Vinicius Junior, 17, came off the bench and scored twice as Flamengo overcame Emelec in the Copa Libertadores.
Racing Club and Atletico Nacional claimed wins as the Copa Libertadores group stage got underway.