Alvaro Morata finally ended his barren streak for Atletico Madrid to set them on their way to victory over Villarreal.
Sevilla will face Slavia Prague in the last 16, while Arsenal have Rennes and Chelsea will take on Dynamo Kiev.
Villarreal have re-hired Javi Calleja as their coach, despite the former defender only being sacked by them in December.
Villarreal, winless in LaLiga since November, have sacked coach Luis Garcia Plaza with the club 19th in Spain's top flight.
Allan will not play for Napoli against AC Milan after a week of speculation over his future, but Carlo Ancelotti does not expect a transfer.
As he prepares for the Australian Open quarters, life could have been different for football fan Roberto Bautista Agut.
Leicester City have allowed Vicente Iborra to return to LaLiga, with the former Sevilla midfielder joining Villarreal for a reported €11m.
Predrag Mijatovic is frustrated by Gareth Bale's injury problems and does not consider him a player on whom Real Madrid can rely.
Bologna have pulled off something of a coup by bringing Nicola Sansone and Roberto Soriano to the club, initially on loan.
Villarreal's comeback against Real Madrid has left the European champions seething, according to Lucas Vazquez.