Gareth Bale's omission from Real Madrid's squad against Villarreal was "not a message", according to Los Blancos coach Zinedine Zidane.
Real Madrid were without the injured Karim Benzema and the dropped Gareth Bale but Mariano Diaz scored twice in a 3-2 win over Villarreal.
Paul Pogba continues to be mooted as a Real Madrid target, but Zinedine Zidane will not discuss possible transfers prematurely.
Copa del Rey finalists Valencia will be without Russia international Denis Cheryshev for the rest of the season due to a knee injury.
Valencia progressed to the Europa League semi-finals by beating Villarreal on Thursday, setting up a clash with Arsenal.
Toni Lato and Dani Parejo were on target for Valencia as Marcelino's side eased into the Europa League semi-finals by beating Villarreal.
Villarreal were made to rue their missed chances against Valencia, with Marcelino accepting the 3-1 win flattered his men.
Valencia will surely be in the Europa League last four after they beat Villarreal 3-1 away from home in their quarter-final first leg.
Arsenal and Villarreal could meet in the Europa League semi-finals - a reunion that would please Santi Cazorla.
Barcelona escaped with a remarkable 4-4 draw against Villarreal and can tighten their grip on LaLiga when they face Atletico Madrid.