"Y'all see that Duke game?" Pierce asked during a segment on NBA After the Buzzer. "They could beat Cleveland."
Harden missed three games because of a strained left hamstring, but made his return in Houston's road win against Chicago on Saturday.
The Cleveland Cavaliers face an extended period without Kevin Love after he underwent surgery on his left foot.
The Cleveland Cavaliers claimed their first win of the NBA season without Kevin Love, who is keen to get back on the floor.
The Cavaliers just fired head coach Tyronn Lue, and they may not have Kevin Love back any time soon.
The Cavaliers informed the players of the decision to fire coach Tyronn Lue on Sunday, though many reportedly are "pissed."
Love will be re-evaluated before Saturday night’s game in Cleveland against the Pacers.
Cleveland has opened 2018-19 with an 0-3 record and suffered a blowout 133-111 loss to the Hawks last weekend.
Butler didn't get a warm welcome at Target Center on Friday, but he changed fans' minds who went from booing the guard to chanting MVP.
The Boston Celtics are the favourites in the East while the Toronto Raptors and Philadelphia 76ers also appear ready to compete.