Diego Forlan, 40, has taken his first steps into senior coaching thanks to former club Penarol in Uruguay.
Wednesday's results left all three teams on 10 points but Flamengo (+6) and LDU Quito (+4) pipped Penarol (+2) on goal difference.
River Plate progressed to the Copa Libertadores knockout stage after a win at Palestino.
Nicolas De La Cruz's spectacular free-kick helped River Plate earn a draw at Internacional in the Copa Libertadores.
Lucas Viatri led Penarol to a comprehensive win over San Jose in the Copa Libertadores.
Cruzeiro edged Huracan in wet conditions, while Deportivo Lara's clash against Emelec had to be rescheduled due to a floodlight issue.
We assess the leading candidates for glory and the potential stars ahead of the start of the 2019 Copa Libertadores.