Jake Trueman and Jesse Sene-Lefao both crossed twice as Castleford cut loose against the struggling Super League champions.
Premiership-winner Carl Rimmer is embarking on life after rugby, having retired due to an artery problem that caused a stroke in training.
Skipper Darius Boyd was among the try scorers as Brisbane Broncos demolished Gold Coast Titans on the road in the NRL.
After a miserable start to the season, Catalans Dragons are in fine form and made it six wins in seven by beating Wakefield on Saturday.
The Jaguares were in control early on in Pretoria, but could not withstand a fightback from the Bulls in Super Rugby.
Canterbury Bulldogs collapsed late on in their clash with Canberra Raiders, as Rhyse Martin's treble was spectacularly cancelled out.
The Waratahs will play post-season Super Rugby thanks to their latest big win, while Ngani Laumape scored four tries for the Hurricanes.
Warrington Wolves' late rally at Wigan Warriors came to nothing and St Helens cruised against Widnes Vikings in the Super League.
Wyatt Crockett's 200th Super Rugby appearance went to plan as the Crusaders, defending champions and league leaders, beat the Highlanders.
Appearing in the NRL for the second time, Jarome Luai was Penrith Panthers' match-winner against New Zealand Warriors.