Nicolas Sanchez has been dropped for Argentina's Rugby World Cup showdown with England on Saturday, while former captain Agustin Creevy is only on the bench.
Fly-half Sanchez, the leading points-scorer at the 2015 World Cup, was surprisingly overlooked by Mario Ledesma for a huge encounter against the Pool C leaders at Tokyo Stadium.
Benjamin Urdapilleta keeps his place at number 10, while hooker Julian Montoya - on a high after scoring a hat-trick against Tonga - retains his spot at the expense of Creevy, who will be hoping to earn a Pumas-record 88th cap off the bench.
Javier Ortega Desio comes back into the side at number eight for what Creevy says will be a "war".
Argentina got up and running with a win over Tonga after making a losing start against France and sit third in Pool C behind England and Les Bleus.
Argentina: Emiliano Boffelli, Matias Moroni, Matias Orlando, Jeronimo de la Fuente, Santiago Carreras, Benjamin Urdapilleta, Tomas Cubelli; Nahuel Tetaz Chaparro, Julian Montoya, Juan Figallo, Guido Petti Pagadizabal, Tomas Lavanini, Pablo Matera (captain), Marcos Kremer, Javier Ortega Desio.
Replacements: Agustin Creevy, Mayco Vivas, Santiago Medrano, Matias Alemanno, Tomas Lezana, Felipe Ezcurra, Lucas Mensa, Bautista Delguy.