South Sydney Rabbitohs lost Adam Reynolds to injury but still managed to see off Wests Tigers and secure a 10th win of the NRL season.
Reynolds will be sent for scans on Sunday after hobbling off during a 32-16 triumph, though the half-back had contributed a try and three goals before his departure with a leg injury.
Cameron Murray crossed twice while Damien Cook and Liam Knight also grabbed tries for the table-topping Rabbitohs, who have made their best start to a season since 1989.
Injuries were also a major talking point in North Queensland Cowboys' 22-16 triumph over Canberra Raiders, as both teams lost key performers during the contest.
The Cowboys made it back-to-back wins despite the loss of prop Matt Scott to a shoulder issue midway through the first half.
Jordan Kahu kicked 10 points while tries from Tom Opacic, Justin O'Neill and Kyle Feldt kept the slumping Raiders, who have now lost three on the spin, at bay.
Ricky Stuart's Canberra side struggled in attack in the second half without the services of co-captain Josh Hodgson, who was withdrawn with a suspected broken thumb.
Meanwhile, the Brisbane Broncos are up to ninth in the ladder after an 8-2 win over the New Zealand Warriors that saw Anthony Milford score the only try.