Eight-try Leigh beat Wigan for the first time since 1984, with Liam Hood crossing twice in quick succession.
Cronulla Sharks' fast-finishing approach was stymied by Melbourne Storm, who hold on to top spot on the NRL ladder.
The St George Illawarra Dragons extended head coach Paul McGregor's contract.
A late Tom Holmes try dug Castleford Tigers out of a hole to extend their advantage at the top of the Super League table.
Daly Cherry-Evans was Manly Sea Eagles' hero as his golden-point field goal saw off the Canberra Raiders.
Wigan Warriors were blown away in the first half by Hull FC as Lee Radford's side claimed a first win in four matches.
Sydney Roosters hung on to a narrow NRL victory over Brisbane Broncos thanks to a missed conversion from Jordan Kahu.
Two Adam Cuthbertson tries helped Leeds Rhinos to a simple win over Leigh Centurions, as Brian McDermott's men kept pace near the top.
NRL leaders Melbourne Storm ran in eight tries as they cruised past Newcastle Knights 40-12 on Friday, Billy Slater their star man.
The St George Illawarra Dragons lost Josh Dugan to Cronulla Sharks but they have managed to tie down Tim Lafai for a further three seasons.