Crystal Palace needed a late equaliser from the returning Wilfried Zaha to avoid defeat against London rivals West Ham.
Manchester United's win at Fulham set them up nicely to face Paris Saint-Germain at Old Trafford, according to Ole Gunnar Solskjaer.
Sadio Mane, Georginio Wijnaldum and Mohamed Salah got the goals as Liverpool returned to winning ways and the Premier League summit.
Ishak Belfodil scored twice as Hoffenheim clawed their way back from three goals down to draw 3-3 with Bundesliga leaders Borussia Dortmund.
Having been treated on the touchline during Leeds United's draw with Middlesbrough, Jack Clarke has gone to hospital for further tests.
Manchester United moved fourth in the Premier League by beating Fulham, and Paul Pogba intends for his side to stay there.
Gareth Bale and Marcelo were named on the bench for Real Madrid, while Diego Godin and Saul Niguez returned to bolster Atletico Madrid.
Anthony Martial and Paul Pogba combined to clinical effect to give Manchester United a comfortable win at Fulham.
AC Milan have the chance to put themselves in a strong position in Serie A, but Gennaro Gattuso has warned against complacency.
After a row with Paulo Dybala and Douglas Costa's car crash, Juventus boss Massimiliano Allegri reflected on an eventful week off the field.