Antonio Conte's Serie A return with Inter will come at home to promoted Lecce, while Juventus' title defence starts with a trip to Parma.
Serie A announced the fixtures for the new campaign on Monday, with the 2019-20 season set to begin on August 25.
It has been an intriguing close season in Italy, with many of the country's top clubs changing coaches.
Conte is now at Inter and former Napoli coach Maurizio Sarri is back in Serie A with defending champions Juve after leaving Chelsea.
AC Milan swapped Gennaro Gattuso for Marco Giampaolo and Roma are now under the tutelage of Paolo Fonseca.
Sarri's new side begin by travelling to Parma, while Milan go to Udinese and Roma host Genoa on the opening weekend.
Matchday one fixtures in full
Cagliari v Brescia
Fiorentina v Napoli
Hellas Verona v Bologna
Inter v Lecce
Parma v Juventus
Roma v Genoa
Sampdoria v Lazio
SPAL v Atalanta
Torino v Sassuolo
Udinese v AC Milan